Dectomax Pour-On for Cattle is a highly active broad spectrum parasiticide for topical
administration to cattle. It contains doramectin, a novel fermentation-derived compound
discovered by Pfizer. Doramectin is isolated from fermentation of selected strains derived
from the soil organism Streptomyces avermitilis.
A primary mode of action of doramectin is to modulate chloride ion channel activity in
the nervous system of nematodes and arthropods. Doramectin binds to receptors that
increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve
cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites.
In mammals the neuronal receptors to which doramectin binds are localised within the central
nervous system (CNS), a site reached by only negligible concentrations of doramectin.
Broad-spectrum: a single treatment with Dectomax Pour-On for Cattle effectively treats
and controls a wide range of internal roundworms and arthropod parasites that impair the
health and productivity of cattle.
Long-action: the sustained drug concentrations that result from its unique pharmacokinetics
enable the product to protect cattle against parasite infection and reinfection for extended
periods following treatment.
Safety: Dectomax Pour-On for Cattle has a wide margin of safety in all classes of cattle.
Its broad spectrum of activity, favourable pharmacokinetics and exceptional toleration make it
an ideal product for application as an antiparasitic for cattle.