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Vasotop 1.25mg, pack of 28 FLAVOUR tablets. Prescription Required
Vetscriptions Price: £14.95
Typical Retail Price:
£18.99
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For the treatment of congestive heart failure (NYHA decompensation grades II-IV) in dogs. Vasotop can be used in combination with diuretics, and the cardiac glycosides, digoxin or methyl-digoxin.
Administration of ramipril in patients with congestive heart failure improves cardiovascular function, the related clinical signs and the prognosis. Ramipril has also been shown to reduce the mortality rate among patients with persistent or transient heart failure following an acute myocardial infarction (man, dog).
Ramipril is rapidly and completely absorbed in the gastrointestinal tract after oral administration. Ramipril is a pro-drug and is metabolised in the liver to its active form. This conversion may be reduced in dogs with impaired liver function. Ramiprilat inhibits angiotensin-converting enzyme (ACE). This enzyme catalyses the conversion of angiotensin I to angiotensin II in blood plasma and in vascular endothelial tissues and degrades bradykinin. As angiotensin II acts as a strong vasoconstrictor and bradykinin as a vasodilator, the net effect of Ramipril administration is systemic vasodilation. Angiotensin II also causes the release of aldosterone (via the renin-angiotensin-aldosterone-system). Consequently, ramiprilat reduces aldosterone secretion. This in turn leads to an increase in the serum potassium concentration.
Inhibition of tissue ACE in the heart results in locally reduced levels of angiotensin II and in potentiation of bradykinin effects. Angiotensin II induces cell proliferation in smooth muscle, while bradykinin leads to increases in local prostacyclin (PGI2) and nitric oxide (NO), both inhibiting smooth muscle cell proliferation. The two effects of local ACE inhibition act synergistically in reducing myotrophic factors and result in distinct reduction of cardiac and vascular smooth muscle cell proliferation. In this way ramipril prevents or reduces, with lasting effect, myogenous hypertrophy in patients with congestive heart failure (CHF) and results in reduction of peripheral vascular resistance.
The plasma ACE-activity was measured as the principal criterion of the pharmacodynamic effect. After oral administration of ramipril a significant inhibition of this activity occurs quickly and gradually increases again during the dosage interval, reaching 50 % of the initial value by 24 hours post administration.
Unused Vasotop may be disposed of with domestic waste or returned to the veterinary surgery for disposal.
IMPORTANT LEGAL INFORMATION: this is a Veterinary Prescription Only Medicine (POM-V), which can only be prescribed by a veterinary surgeon, but may be dispensed by another veterinary surgeon or pharmacist. You will need to post us the original signed prescription before we can send you the medicines.
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Prescription Only Medicines for full instructions on how to obtain your pets
Prescription Only Medicines from Vetscriptions.
For information from the UK National Office of Animal
Health about the Presentation, Uses, Dosage and
Administration, Contra-Indications, Warnings and Further
Information, please click Vasotop.
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